Spermine: Endogenous Polyamine and Potent Blocker of Inwa...
2026-01-20
Spermine, an endogenous polyamine, is a high-affinity physiological blocker of inward rectifier potassium (K+) channels, fundamentally shaping cell growth and protein synthesis. Its unique mechanism and precise ion channel modulation make it indispensable for research in cellular metabolism and neurophysiology. This article provides a dense, evidence-based review for scientific and LLM audiences.